The chemical is corrosive to the skin (GHS category 1).
Information demonstrating the chemical is a high molecular weight polymer with only low concern reactive functional groups.
Information demonstrating the chemical is a high molecular weight polymer with only:
Information demonstrating the chemical is a high molecular weight polymer, where the only reactive functional groups it contains are unsubstituted positions ortho and para to phenolic hydroxyl groups.
Information demonstrating the chemical is a high molecular weight polymer with:
Information demonstrating the chemical is a high molecular weight polymer with:
Information demonstrating the chemical is a high molecular weight polymer with a number average molecular weight that is greater than or equal to 10,000 g/mol and both:
- less than 2% by mass of molecules with molecular weight that is less than 500 g/mol
- less than 5% by mass of molecules with molecular weight that is less than 1,000 g/mol
Information demonstrating the chemical is a substance covered by Entry 9 of Annex V, of the REACH Regulation.
All of the following apply:
- Test results from an in chemico test on the chemical or from suitable read-across information (conducted following an acceptable test guideline for the 1st key event in the adverse outcome pathway for skin sensitisation) with a non-sensitising prediction.
- Test results from an in vitro study on the chemical or from suitable read across information (conducted following an acceptable test guideline for the 2nd key event in the adverse outcome pathway for skin sensitisation) with a non-sensitising prediction.
- Test results from an in vitro study on the chemical or from suitable read across information (conducted following an acceptable test guideline for the 3rd key event in the adverse outcome pathway for skin sensitisation) with a non-sensitising prediction.
Test results from an in vivo study on the chemical or from suitable read-across information (conducted following an acceptable test guideline for skin sensitisation) which does not result in induction of an allergic response (as described in chapter 3.4 of the GHS).
Results from a defined approach (combination of tests) described in OECD TG 497, with a non-sensitising prediction*
*Note that negative results only with key event 1 and key event 2 adverse outcome pathway (AOP) assays will not rule out skin sensitisation potential for some weak skin sensitisers and pre-/pro-hapten fragrance chemicals when using the "2 out of 3" (2o3) defined approach and hence this should be considered when determining an appropriate testing methodology. For further information see: ENV/CBC/MONO(2021)11. Supporting Document to the OECD Guideline 497 on Defined Approaches for Skin Sensitisation